Children's Hospital Boston

Rowitch DH, Echelard Y, Danielian PS, Gellner K, Brenner S, McMahon AP. Identification of an evolutionarily conserved 110 base-pair cis-acting regulatory sequence which governs Wnt-1 expression in the murine neural plate. Development 1998; 125:2735-2746.

Rowitch DH, St.-Jacques B, Lee S, Flax J, Snyder E, McMahon AP. Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J Neurosci 1999; 19:8954-8965.

Lu QR, Yuk D, Alberta J, Zhu Z, Pawlitzky I, McMahon AP, Stiles CD, Rowitch DH. Sonic hedgehog-regulated Oligodendrocyte lineage genes encoding bHLH factors in the mammalian central nervous system. Neuron 2000; 25:317-329.

Kenney AM, Rowitch DH. Sonic hedgehog Promotes G₁ Cyclin Expression and Sustained Cell Cycle Progression in Mammalian Neuronal Precursors. Mol Cell Bio 2000; 20: 9055-9067.

Lu QR, Park J, Noll e, Chan JA, Alberta J, Yuk D, Garcia Alzamora M, Louis DN, Stiles Cd, Rowitch dH, Black PM. Oligodendrocyte lineage genes (OLIG) as as molecular markers for human glial brain tumors. PNAS 2001;98:10851-10856.

Sun T, Echelard Y, Lu R, Yuk D, Kaing S, Stiles CD, Rowitch DH. Olig basic helix-loop-helix proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. Curr Biol 2001;18:1413-1420.

Lu QR, Cai L, Rowitch DH, Cepko CL, Stiles CW. Ectopic expression of Olig 1 promotes formation of oligodendrocytes and is deleterious to neuronal survival in developing mouse cortex. Nat Neurosci 2001;10:973-974.

Alberta J, Park-S-K., Mora J, Yuk D, Pawlitzky I, Iannarelli P, Vartanian T, Stiles CD, Rowitch DH. Sonic hedgehog signaling is required during an early phase of oligodendrocyte development in the mammalian brain. MCN 2001;18:434-444.

Ciemerych MA, Kenney AM, Sicinska E, Kalaszczynska I, Bronson RT, Rowitch DH, Gardner H, Sicinski P. Development of mice expressing a single D-type cyclin. Genes Dev 2002;16:3277-3289.

Rubin JB, Rowitch DH. Medulloblastoma: a problem of developmental biology. Cancer Cell 2002;2:7-8.

Rowitch DH, Lu QR, Kessaris N, Richardson WD. An 'oligarchy' rules neural development. TINS 2002;25(8):417-22.

Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 2002;1(3):269-77.

Zhao Q, Kho A, Kenney AM, Yuk Di DI, Kohane I, Rowitch DH. Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach. PNAS USA 2002;99(8):5704-9.

Lu QR, Sun T, Zhu Z, Ma N, Garcia M, Stiles CD, Rowitch DH. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell 2002;109(1):75-86.

Ciernerych MA, Kenney AM, Sichinska AM, Kalaszczynska EI, Bronson RT, Rowitch DH, Segal RA, Pomeroy SL. Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice. Dec Viol 2002;263:50-66.

Ligon KL, Echelard Y, Assimacopoulos S, Danielian PS, Kaing S, Grove EA, McMahon AP, Rowitch DH. Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia. Development 2003;130(10):2275-87.

Kim JY, Nelson AL, Algon SA, Graves O, Sturla LM, Goumnerova LC, Rowitch DH, Segal RA, Pomeroy SL. Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice. Dev Biol 2003;263(1):50-66.

Sun T, Dong H, Wu L, Kane M, Rowitch DH, Stiles CD. Links cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex. J Neurosci 2003;23(29):9547-56.

Kenney AM, Widlund HR, Rowitch DH. Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development 2004;131(1):217-28.

Ligon KL, Alberta JA, Kho AT, Weiss J, Kwaan MR, Nutt CL, Louis DN, Stiles CD, Rowitch DH. The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropath Exp Neurol 2004, in press.

Kho AT, Zhao Q, Cai Z, Butte AJ, Pomeroy SL, Rowitch DH, Kohane IS. Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev 2004, in press.




		Publications Rowitch DH, Echelard Y, Danielian PS, Gellner K, Brenner S, McMahon AP. Identification of an evolutionarily conserved 110 base-pair cis-acting regulatory sequence which governs Wnt-1 expression in the murine neural plate. Development 1998; 125:2735-2746. Rowitch DH, St.-Jacques B, Lee S, Flax J, Snyder E, McMahon AP. Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J Neurosci 1999; 19:8954-8965. Lu QR, Yuk D, Alberta J, Zhu Z, Pawlitzky I, McMahon AP, Stiles CD, Rowitch DH. Sonic hedgehog-regulated Oligodendrocyte lineage genes encoding bHLH factors in the mammalian central nervous system. Neuron 2000; 25:317-329. Kenney AM, Rowitch DH. Sonic hedgehog Promotes G₁ Cyclin Expression and Sustained Cell Cycle Progression in Mammalian Neuronal Precursors. Mol Cell Bio 2000; 20: 9055-9067. Lu QR, Park J, Noll e, Chan JA, Alberta J, Yuk D, Garcia Alzamora M, Louis DN, Stiles Cd, Rowitch dH, Black PM. Oligodendrocyte lineage genes (OLIG) as as molecular markers for human glial brain tumors. PNAS 2001;98:10851-10856. Sun T, Echelard Y, Lu R, Yuk D, Kaing S, Stiles CD, Rowitch DH. Olig basic helix-loop-helix proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. Curr Biol 2001;18:1413-1420. Lu QR, Cai L, Rowitch DH, Cepko CL, Stiles CW. Ectopic expression of Olig 1 promotes formation of oligodendrocytes and is deleterious to neuronal survival in developing mouse cortex. Nat Neurosci 2001;10:973-974. Alberta J, Park-S-K., Mora J, Yuk D, Pawlitzky I, Iannarelli P, Vartanian T, Stiles CD, Rowitch DH. Sonic hedgehog signaling is required during an early phase of oligodendrocyte development in the mammalian brain. MCN 2001;18:434-444. Ciemerych MA, Kenney AM, Sicinska E, Kalaszczynska I, Bronson RT, Rowitch DH, Gardner H, Sicinski P. Development of mice expressing a single D-type cyclin. Genes Dev 2002;16:3277-3289. Rubin JB, Rowitch DH. Medulloblastoma: a problem of developmental biology. Cancer Cell 2002;2:7-8. Rowitch DH, Lu QR, Kessaris N, Richardson WD. An 'oligarchy' rules neural development. TINS 2002;25(8):417-22. Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 2002;1(3):269-77. Zhao Q, Kho A, Kenney AM, Yuk Di DI, Kohane I, Rowitch DH. Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach. PNAS USA 2002;99(8):5704-9. Lu QR, Sun T, Zhu Z, Ma N, Garcia M, Stiles CD, Rowitch DH. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell 2002;109(1):75-86. Ciernerych MA, Kenney AM, Sichinska AM, Kalaszczynska EI, Bronson RT, Rowitch DH, Segal RA, Pomeroy SL. Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice. Dec Viol 2002;263:50-66. Ligon KL, Echelard Y, Assimacopoulos S, Danielian PS, Kaing S, Grove EA, McMahon AP, Rowitch DH. Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia. Development 2003;130(10):2275-87. Kim JY, Nelson AL, Algon SA, Graves O, Sturla LM, Goumnerova LC, Rowitch DH, Segal RA, Pomeroy SL. Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice. Dev Biol 2003;263(1):50-66. Sun T, Dong H, Wu L, Kane M, Rowitch DH, Stiles CD. Links cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex. J Neurosci 2003;23(29):9547-56. Kenney AM, Widlund HR, Rowitch DH. Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development 2004;131(1):217-28. Ligon KL, Alberta JA, Kho AT, Weiss J, Kwaan MR, Nutt CL, Louis DN, Stiles CD, Rowitch DH. The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropath Exp Neurol 2004, in press. Kho AT, Zhao Q, Cai Z, Butte AJ, Pomeroy SL, Rowitch DH, Kohane IS. Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev 2004, in press. See Dr. Rowitch's publications via PubMed