Publications

Yankner BA. Mechanisms of neuronal degeneration in Alzheimer’s disease. Neuron 1996; 16:921-932.

Yankner BA. New clues to Alzheimer’s disease: Unraveling the roles of amyloid and tau. Nature Med 1996; 2:850-851.

Lorenzo A, Yankner BA. Amyloid fibril toxicity in Alzheimer’s disease and diabetes. Ann NY Acad Sci 1996; 777:89-95.

Baumann K, Paganetti P, Sturchler-Pierrat C, Wong C, Hartmann H, Cescato R, Frey P, Yankner BA, Sommer B, Staufenbiel M. Distinct processing of endogenous and overexpressed recombinant presenilin 1. Neurobiol Aging 1997; 18:181-189.

Hartmann H, Busciglio J, Baumann K, Staufenbiel M, Yankner BA. Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation. J Biol Chem 1997; 272:14505-14509.

Busciglio J, Hartmann H, Lorenzo A, Wong C, Baumann K, Sommer B, Staufenbiel M, Yankner BA. Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer’s disease. J Neurosci 1997; 17:5101-5107.

Yankner BA. Monster plaques: What they tell us about Alzheimer’s disease. Nature Med 1998; 4:394-395.

Geula C, Wu C-K, Saroff D, Lorenzo A, Yuan M, Yankner BA. Aging renders the brain vulnerable to amyloid b-protein neurotoxicity. Nature Med 1998; 4:827-831.

Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, DeStrooper B, He X, Yankner BA. Destablization of b-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 1998; 395:698-702.

Liu C, Kato Y, Zhang Z, Do VM, Yankner BA, He X. Beta Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proc Natl Acad Sci USA 1999; 96:6273-6278.

Song W, Nadeau P, Yuan M, Yang X, Shen J, Yankner BA. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proc Natl Acad Sci USA 1999; 96:6959-6963.

Yuan J, Yankner BA. Caspase activity sows the seeds of neuronal death. Nature Cell Biol 1999; 1:44-45.

Hartmann H, Yankner BA. Normal proteolytic processing of presenilins. Meth Molec Med 1999, 32:297-308.

Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic reticulum-specific apoptosis and cytotoxicity by amyloid-b. Nature 2000; 403:98-103.

Yankner BA. Cognitive decline in the twentieth century. Nature 2000; 404:125.

Lorenzo A, Yuan M, Zhang Z, Paganetti PA, Sturchler-Pierrat C, Staufenbiel M, Mautino J, Sol Vigo F, Yankner BA. Amyloid b interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer’s disease. Nature Neurosci 2000; 3:460-464.

Yuan J, Yankner BA. Apoptosis in the nervous system. Nature 2000;407(6805):802-9.

Zhang Z, Nadeau P, Song W, Donoviel D, Yuan M, Bernstein A, Yankner BA. Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1. Nat Cell Biol 2000;2(7):463-5.

Weninger SC, Yankner BA. Inflammation and Alkzheimer's disease: The good, the bad, and the ugly. Nature Med 2001;7:527-528.

Busciglio J, Pelsman A, Wong C, Pigino G, Yuan M, Mori H, Yankner BA. Altered metabolism of amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron 2001;33:677-688.

Ebinu JO, Yankner BA. A RIP tide in neuronal signal transduction. Neuron 2002;34(4):499-502.

Xu J, Kao SY, Lee FJ, Song W, Jin LW, Yankner BA. Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat Med 2002;8(6):600-6.

Chen F, Tandon A, Sanjo N, Gu YJ, Hasegawa H, Arawaka S, Lee FJ, Ruan X, Mastrangelo P, Erdebil S, Wang L, Westaway D, Mount HT, Yankner B, Fraser PE, St George-Hyslop P. Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain. J Biol Chem 2003;278(22):19974-9.

See Dr. Yankner's publications via PubMed